Detection of TT virus DNA in plasma-derived clotting factor concentrates.
نویسندگان
چکیده
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منابع مشابه
TT virus is present in a high frequency of Italian hemophilic patients transfused with plasma-derived clotting factor concentrates.
The prevalence of the blood-borne TT virus (TTV) in Italian hemophiliacs treated with different preparations of factor VIII was determined. Of the 178 hemophilic patients (mean age, 29 years), TTV-DNA was found in 123 (69%), in comparison to 22 of 100 (22%) blood donors (P <.0001). Of the 123 patients who tested positive for TTV, significant numbers were also infected with human hepatitis virus...
متن کاملBrief report TT virus contaminates first-generation recombinant factor VIII concentrates
Recombinant factor VIII and factor IX concentrates, human-plasma–derived albumin, and samples from previously untreated patients with hemophilia were examined for the presence of TT virus (TTV) by using polymerase chain reaction testing. Blood samples from the patients were obtained prospectively before and every 3 to 6 months after therapy was begun. TTV was detected in 23.5% of the recombinan...
متن کاملMixed Genotypes in Hepatitis C Virus Infection
Before the existence of commercial clotting factor concentrates, bleeding was the number one cause of death in persons with hemophilia and the only alternative treatment was cryoprecipitate. During the 1970s human freeze-dried (lyophilized) FVIII and FIX became available. The life of individuals with hemophilia was revolutionized because patients were able to treat themselves conveniently at ho...
متن کاملTT virus contaminates first-generation recombinant factor VIII concentrates.
Recombinant factor VIII and factor IX concentrates, human-plasma-derived albumin, and samples from previously untreated patients with hemophilia were examined for the presence of TT virus (TTV) by using polymerase chain reaction testing. Blood samples from the patients were obtained prospectively before and every 3 to 6 months after therapy was begun. TTV was detected in 23.5% of the recombinan...
متن کاملRecombinant clotting factors.
The recombinant era for haemophilia began in the early 1980s with the cloning and subsequent expression of functional proteins for both factors VIII and IX. Efficient production of recombinant clotting factors in mammalian cell culture systems required overcoming significant challenges due to the complex post-translational modifications that were integral to their pro-coagulant function. The qu...
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ورودعنوان ژورنال:
- Blood
دوره 94 10 شماره
صفحات -
تاریخ انتشار 1999